Bästa Justice O Connor podcaster (2024)

1
EP 153: How genomics is re-writing the taxonomy of disease with Lon Cardon, President and CEO of The Jackson Laboratory 40:25

1d ago40:25

40:25

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lon 01:51 Lon’s involvement in the very first GWAS and what drew him to large-scale genomics research 03:32 Was moving away from candidate genes towards GWAS and data sharing initially a controversial idea? 05:25 What Lon believes has driven collaboration and data sharing within research communiti…

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EP 152: Unlocking the secrets of gene regulation with Nadav Ahituv, Director of the Institute of Human Genetics at UCSF 42:40

9d ago42:40

42:40

01:15 - Introductions 02:02 - How our understanding of the non-coding genome has evolved throughout Nadav’s career 04:56 - Our current understanding of non-coding genome grammar 07:40 - Is there a missing piece to the common variant, common disease paradigm? 10:25 - Introducing ultraconserved elements (UCEs) and human accelerated regions (HARs) 12:…

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How Stereotypes Affect Us and What We Can Do 59:23

18d ago59:23

59:23

Today, we share a conversation that looks at the impact of stereotypes, how they affect us, and what we can do to limit their adverse effects. This discussion is led by Stanford Professor Dr. Claude M. Steele, an expert on social psychology, and initially took place as part of our Constitution Series Webcasts focusing on Equality and Justice for Al…

1
EP 151: Understanding cell ageing and its role in disease with Marco Quarta Co-founder and CEO of Rubedo Life Sciences 42:36

16d ago42:36

42:36

0:00 Intro to The Genetics Podcast 01:00 Welcome to Marco 02:00 The areas Marco focused on during his academic career and what motivated him to found his first company 03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology 06:01 How to get a clearer picture of the ageing p…

1
A Landmark Case - Brown v. Board of Education 59:28

24d ago59:28

59:28

As students return to classrooms across the country this fall, we are resharing important conversations on landmark cases related to education. Today, we look at one of the most important Supreme Court decisions of the 20th Century - Brown v. Board of Education. This detailed conversation with Cheryl Brown Henderson, daughter of the late Rev. Olive…

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EP 150: Cracking the biological code of aging with Martin Borch Jensen, Co-Founder and Chief Scientific Officer at Gordian Biotechnology 44:21

25d ago44:21

44:21

0:00 Intro to The Genetics Podcast 01:00 Welcome to Martin 01:35 How a particularly large Indian meal resulted in a book about intermittent fasting and the biology of ageing 05:10 The biological mechanisms behind intermittent fasting, and whether it’s been established to extend life expectancy in humans. 10:13 What we know (and what we don’t) about…

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EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre 34:16

1M ago34:16

34:16

0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…

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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School 35:13

1M ago35:13

35:13

0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…

1
How Are Secretaries of State Preparing for the November Election? 41:01

2M ago41:01

41:01

As preparations for the 2024 General Election approach, the Sandra Day O’Connor Institute for American Democracy sat down with the National Association of Secretaries of State (NASS) President Secretary Steve Simon (D-MN), President-elect Michael Watson (R-MS), and NASS Executive Director Leslie Reynolds to discuss important bipartisan aspects of e…

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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University 37:19

2M ago37:19

37:19

0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…

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#56 - The 1966 Superman Broadway Musical (feat. Matt Truex) 1:52:05

2M ago1:52:05

1:52:05

"Who is the man you can't ignore, it's SUPERMAN! From Budapest to Baltimore it's SUPERMAN!" Alan and Rob are joined once again by long-time friend of the show Matt Truex as they delve into the weird and wonderful history of the ill-fated (and yet indestructible) 1966 Broadway musical version of Superman. Fascinating connections with the Superman mo…

1
Equality and Justice for All, with Dr. Spencer Crew 1:00:24

2M ago1:00:24

1:00:24

We are pleased to take a new look at this conversation with Dr. Spencer Crew, in which he discusses the importance of making African American history accessible to the public. Art and documents in a museum can be an important way to experience and understand cultures in new ways. Dr. Spencer Crew has worked in public history institutions for more t…

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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital 43:05

2M ago43:05

43:05

0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…

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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor 39:12

2M ago39:12

39:12

0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…

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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's 56:48

2M ago56:48

56:48

0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …

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#55 - Exclusive interview with JUSTICE LEAGUE UNLIMITED's Superman GEORGE NEWBERN 30:19

2M ago30:19

30:19

"What we have here is a rare opportunity for me to cut loose, and show you just how powerful I really am!" Alan & Rob are excited to be joined by none other than the voice of Clark Kent/Superman himself, actor George Newbern. Star of iconic 80’s and 90’s films such as ‘Adventures in Babysitting’ and the ‘Father of the Bride’ movie franchise, George…

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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

2M ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

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The Company Trump Keeps: From David Duke to The Proud Boys to Project 2025 – Intended Consequences 26:02

3M ago26:02

26:02

In this episode, the hosts discuss Project 2025 and its potential impact in a Donald Trump administration. Heritage Foundation and Trump https://www.heritage.org/impact/trump-administration-embraces-heritage-foundation-policy-recommendations Biden’s Judicial Appointments https://www.pewresearch.org/short-reads/2023/12/04/most-of-bidens-appointed-ju…

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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

3M ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

1
The Future of Urban America 40:37

3M ago40:37

40:37

Empty office buildings. Workforce changes allow for more remote work. American downtowns are struggling. The pandemic-led changes in where and how we work and live have weakened and withered many urban cores. The office vacancy rate in Houston is some 26 percent; in Phoenix it is above 20 percent. This shift means fewer workers, fewer businesses to…

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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

3M ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

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"A More or Less Perfect Union" with Judge Douglas Ginsburg 57:08

3M ago57:08

57:08

We are excited to revisit this fascinating discussion with Judge Douglas Ginsburg as he delves into past, present, and future struggles for liberty through the lens of the US Constitution - just in time for the 4th of July and the celebration of our Country’s independence. Judge Ginsburg is the author of Voices of Our Republic, the companion to the…

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#54 - The Menace of METALLO (feat. Zach Moore) PLUS: James Gunn's Superman Set Photos! 2:11:52

3M ago2:11:52

2:11:52

"I can't even feel a kiss, what did they do to me?!" Rob and Alan are joined once again by 'Always Hold Onto Smallville''s Zach Moore to discuss the various other media versions of METALLO! We deep dive into the characters' various iterations in comic books, animation and live action and we even explore different avenues for how the Kryptonite-hear…

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Ep 50. Mary Ellen Iskenderian, President and CEO Women's World Banking: There's nothing micro about a billion women! 48:17

3M ago48:17

48:17

"Empowerment is the ability to make choices... and... having economic tools, economic resources is a way of providing the means for those choices." The world has come a long way since 1974 when women in America could not have their own bank account or checking account without their husband’s signature. The 1st United Nations World Conference on Wom…

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John Locke: The 17th Century Philosopher who Shaped American Thought 58:21

3M ago58:21

58:21

The Sandra Day O’Connor Institute for American Democracy presents a conversation with author and historian Claire Rydell Arcenas and Liam Julian, director of Public Policy at the Sandra Day O'Connor Institute. In her book America's Philosopher: John Locke in American Intellectual Life, Rydell Arcenas seeks to better understand and illuminate the cr…

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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

3M ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

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Voting is a Fundamental Right: Exercise It; You’ll Make It Stronger 21:59

3M ago21:59

21:59

In this episode, the hosts begin a series of discussions on the historical significance of voting, efforts to prevent some groups from voting, and why you should exercise your right to vote even if you don’t like the choices. Do what you can, where you are, with what you have. Southern Strategy - In American politics, the Southern strategy was a Re…

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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

3M ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

4M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

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#53 - Does the John Byrne MAN OF STEEL miniseries hold up? 2:50:41

4M ago2:50:41

2:50:41

"It was Krypton that made me Superman, but it's the Earth that makes me human." Alan and Rob take a look back on John Byrne's seminal 1986 MAN OF STEEL miniseries, the book that changed Superman forever. How does its fast-paced storytelling hold up? How did Byrne's decisions have ramifications for the ensuing decades of Superman (and DC) storytelli…

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Talking Revolution, with Nathan Perl-Rosenthal 49:17

4M ago49:17

49:17

There is broad scholarly agreement that our current political world owes much to what Thomas Paine was the first to call the "age of revolutions"—that is, the several late eighteenth- and early nineteenth-century decades during which revolutions rocked the globe. But what gave rise to the age of revolutions? Why, suddenly, were era-spanning monarch…

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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

4M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

4M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

5M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

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EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

5M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

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#52 - James Gunn's Superman costume reveal PLUS! A celebration of Fleischer Superman with Michael Bailey 1:54:11

5M ago1:54:11

1:54:11

With the reveal of the full Superman costume from James Gunn's new "SUPERMAN" film hot off the presses, Alan and Rob give their immediate reaction. Plus - the lads are joined once again by esteemed Superman podcaster Michael Bailey to examine the seminal Superman animated films produced by Fleischer Studios in the 1940s. The panel discusses the imp…

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Ep 49. Dianne Calvi, President & CEO Village Enterprise: Full bellies and big dreams! 58:17

5M ago58:17

58:17

With an audacious goal to lift 20m people in Africa out of extreme poverty by 2030, Dianne Calvi, President and CEO of Village Enterprise, joins us to share how they plan to make this happen. Centred around their core value of ‘Ubuntu’, a South African term, which means ‘humanity’ or ‘I am because we are’, Village Enterprise seeks to transform live…

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EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

5M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

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What's the Deal with the Electoral College? 49:37

5M ago49:37

49:37

Perhaps no extant product of the U.S. Constitution has received more bipartisan animus than the Electoral College. Since 1800 there have been more than 700 proposals introduced in Congress to amend or eliminate the way in which America chooses its presidents. Yet the Electoral College lives on. Why do we have this system? Why does it inspire such c…

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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

5M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

5M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

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EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

6M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

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#51 - INTERVIEW with 'Superman & Lois' staff writer ADAM MALLINGER 1:35:23

6M ago1:35:23

1:35:23

Alan & Rob are joined by ‘Superman & Lois’ staff writer, Adam Mallinger to chat all about working on the first three seasons incredible series, from missing out on working on another CW show to landing his dream job writing the Man of Steel, from peppering the show with callbacks to previous live action iterations, to the crushing difficulties of w…

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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

6M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

6M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

6M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

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EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

7M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

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EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

7M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

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#50 - Superman LEGACY no more! Plus: A Special Message from Mark Waid, Last Days of Lex Luthor and Supergirl Woman of Tomorrow 1:46:02

7M ago1:46:02

1:46:02

Rob and Alan unite in person for the first time ever for this bumper 50th episode extravaganza covering ALL of the latest Superman movie news - Legacy begone as James Gunn has now renamed the movie! What of the ballooning cast? Or the new/old logo? Will Fantastic Four's similar release date hurt Superman's chances? All of these choices and changes …

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Ep 48. Cherie Blair CBE KC, Founder, Cherie Blair Foundation for Women: Enabling economic gender justice 55:58

7M ago55:58

55:58

“There is a problem! Business has a problem, the world has a problem, because we are just not utilising the talents, the ambitions, the drive of half the world’s population (the female half)... Economic gender justice is essential both for women’s freedom and equality, but also for the development of the world.” We are honoured to have on the podca…

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Justice O Connor podcaster

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