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Can We Outsmart Viruses by Targeting Their Shared Weakness?

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Manage episode 443187752 series 3555208
Innehåll tillhandahållet av MedEvidence Articles. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av MedEvidence Articles eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

In this episode, we take a microscopic look at how some of the most dangerous RNA viruses, like COVID-19, Ebola, RSV, and the flu, hijack our cells to replicate. Discover the science behind viral reproduction and RNA-dependent RNA polymerase, the specialized machinery these viruses rely on. We’ll also explore how new antiviral treatments based on Remdesivir are being developed to target this shared vulnerability, offering hope for fighting multiple viruses with a single strategy. Join us for a fascinating dive into the microscopic world of viruses and cutting-edge medical research.
Participate in clinical research!
www.ENCOREdocs.com

Share with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.
Follow us on Social Media:
Facebook
Instagram
Twitter
LinkedIn
Tiktok
For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.com
Thank you for listening!
References:

Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., ... & Kuhn, J. H. (2018). Taxonomy of the order Mononegavirales: update 2018. Archives of virology, 163, 2283-2294. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076851/
Fearns, R., & Deval, J. (2016). New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral research, 134, 63-76. https://www.sciencedirect.com/science/article/pii/S0166354216303527
Gordon, C. J., Tchesnokov, E. P., Woolner, E., Perry, J. K., Feng, J. Y., Porter, D. P., & Götte, M. (2020). Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. Journal of Biological Chemistry, 295(20), 6785-6797. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242698/
International Committee on Taxonomy of Viruses Executive Committee. (2020). The new scope of virus taxonomy: partitioning the virosphere into 15 hierarchical ranks. Nature Microbiology, 5, 668–674. https://www.nature.com/articles/s41564-020-0709-x
Jiang, Y., Yin, W., & Xu, H. E. (2021). RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19. Biochemical and biophysical research communications, 538, 47-53. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473028/
Yan, V. C., & Muller, F. L. (2020). Advantages of the parent nucleoside GS-441524 over remdesivir for Covid-19 treatment. ACS medicinal chemistry letters, 11(7), 1361-1366.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315846/
Xie, J., & Wang, Z. (2021). Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment. Acta Pharmaceutica Sinica B, 11(6), 1607-1616. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245906/

  continue reading

37 episoder

Artwork
iconDela
 
Manage episode 443187752 series 3555208
Innehåll tillhandahållet av MedEvidence Articles. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av MedEvidence Articles eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

In this episode, we take a microscopic look at how some of the most dangerous RNA viruses, like COVID-19, Ebola, RSV, and the flu, hijack our cells to replicate. Discover the science behind viral reproduction and RNA-dependent RNA polymerase, the specialized machinery these viruses rely on. We’ll also explore how new antiviral treatments based on Remdesivir are being developed to target this shared vulnerability, offering hope for fighting multiple viruses with a single strategy. Join us for a fascinating dive into the microscopic world of viruses and cutting-edge medical research.
Participate in clinical research!
www.ENCOREdocs.com

Share with a friend. Rate, Review, and Subscribe to the ENCORE Research Group podcast to be notified when new episodes are released.
Follow us on Social Media:
Facebook
Instagram
Twitter
LinkedIn
Tiktok
For more great content, including discussions by physicians and clinical research experts, check out the MedEvidence podcast. www.MedEvidence.com
Thank you for listening!
References:

Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., ... & Kuhn, J. H. (2018). Taxonomy of the order Mononegavirales: update 2018. Archives of virology, 163, 2283-2294. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076851/
Fearns, R., & Deval, J. (2016). New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral research, 134, 63-76. https://www.sciencedirect.com/science/article/pii/S0166354216303527
Gordon, C. J., Tchesnokov, E. P., Woolner, E., Perry, J. K., Feng, J. Y., Porter, D. P., & Götte, M. (2020). Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency. Journal of Biological Chemistry, 295(20), 6785-6797. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242698/
International Committee on Taxonomy of Viruses Executive Committee. (2020). The new scope of virus taxonomy: partitioning the virosphere into 15 hierarchical ranks. Nature Microbiology, 5, 668–674. https://www.nature.com/articles/s41564-020-0709-x
Jiang, Y., Yin, W., & Xu, H. E. (2021). RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19. Biochemical and biophysical research communications, 538, 47-53. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473028/
Yan, V. C., & Muller, F. L. (2020). Advantages of the parent nucleoside GS-441524 over remdesivir for Covid-19 treatment. ACS medicinal chemistry letters, 11(7), 1361-1366.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315846/
Xie, J., & Wang, Z. (2021). Can remdesivir and its parent nucleoside GS-441524 be potential oral drugs? An in vitro and in vivo DMPK assessment. Acta Pharmaceutica Sinica B, 11(6), 1607-1616. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245906/

  continue reading

37 episoder

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