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Innehåll tillhandahållet av Sano Genetics. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Sano Genetics eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.
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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick
Manage episode 393540661 series 2631947
Innehåll tillhandahållet av Sano Genetics. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Sano Genetics eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
187 episoder
Dela
Manage episode 393540661 series 2631947
Innehåll tillhandahållet av Sano Genetics. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Sano Genetics eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
187 episoder
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Liknande The Genetics Podcast
How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
…
continue reading
A myriad of AI, science, and technology experts explore the real challenges and enormous opportunities facing entrepreneurs who are building the future of health. Raising Health, a podcast by a16z Bio + Health and hosted by Kris Tatiossian and Olivia Webb, dives deep into the heart of biotechnology and healthcare innovation. Join veteran company builders, operators, and investors Vijay Pande, Julie Yoo, Vineeta Agarwala, and Jorge Conde, along with distinguished guests like Mark Cuban, Greg ...
…
continue reading
How many organs could you donate and remain alive? How many planet Earths could fit inside the Sun? How high is a giraffe's blood pressure? Why is the sea blue? To find out, Ask The Naked Scientists!
…
continue reading
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
…
continue reading
Deep in the back of your mind, you’ve always had the feeling that there’s something strange about reality. There is. Join Robert Lamb and Joe McCormick as they examine neurological quandaries, cosmic mysteries, evolutionary marvels and our transhuman future.
…
continue reading
The Science Show gives Australians unique insights into the latest scientific research and debate, from the physics of cricket to prime ministerial biorhythms.
…
continue reading
Flash Forward is a show about possible (and not so possible) future scenarios. What would the warranty on a sex robot look like? How would diplomacy work if we couldn’t lie? Could there ever be a fecal transplant black market? (Complicated, it wouldn’t, and yes, respectively, in case you’re curious.) Hosted and produced by award winning science journalist Rose Eveleth, each episode combines audio drama and journalism to go deep on potential tomorrows, and uncovers what those futures might re ...
…
continue reading
Whether the topic is popcorn or particle physics, you can count on BrainStuff to explore -- and explain -- the everyday science in the world around us.
…
continue reading
Artificial Intelligence has suddenly gone from the fringes of science to being everywhere. So how did we get here? And where's this all heading? In this new series of Science Friction, we're finding out.
…
continue reading
Embedded is the show for people who love gadgets. Making them, breaking them, and everything in between. Weekly interviews with engineers, educators, and enthusiasts. Find the show, blog, and more at embedded.fm.
…
continue reading
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