740: Targeting Complex Sugars on Cell Surfaces to Treat Multiple Sclerosis and Cancer - Dr. Michael Demetriou

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Dr. Michael Demetriou is Director of the National Multiple Sclerosis Society Designated Comprehensive Care Clinic, Professor of Neurology, and Chief of the Division of Multiple Sclerosis and Neuroimmunology at the University of California, Irvine (UCI) School of Medicine. In his research, Mike studies the biological roles of complex sugars called glycans. Glycans are mostly found outside of cells and on cell surfaces. They form a dense forest around the surface of cells and can interact with other proteins to regulate cellular function through interactions with other cell surface proteins. Mike’s lab is interested in how these cell surface glycans influence biology and disease, particularly in autoimmune diseases like multiple sclerosis (MS) and in diseases like cancer where there are commonly abnormalities in these glycans. Mike is also a big fan of the Toronto Maple Leafs hockey team. While he doesn’t play hockey himself anymore, he loves watching professional hockey games and seeing the Maple Leafs play whenever they are in town. He was awarded his MD and his PhD in molecular genetics from the University of Toronto. Mike completed his residency in Neurology at the University of Toronto as well and completed his postdoctoral fellowship at the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. He has received a variety of awards and honors in his career, including being named a Fellow of the Royal College of Physicians and Surgeons in Canada. In addition, he has received UCI’s College of Medicine Committee on Research Award, the Health Science Partners Research Award, the Academic Senate Distinguished Service Award, and the Dr. S. Van Den Noort Research Award for Junior Faculty. In our interview, Mike shares more about his life and science.