#24 - Lipidomics and how future cholesterol tests will diagnose cancers and more

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This week we will dip a toe into Lipidomics, the direction of cholesterol tests in the future; not just looking at lipid blood levels but using the lipid tests as a reflection of changes within our cell membranes. We then look at a state of play article for current available lipid blood tests and how to interpret panels, a keto diet study and a remind ourselves how good bariatric surgery is for people.
References:
Episode 24

Lauber C, Gerl MJ, Klose C, Ottosson F, Melander O, Simons K. Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort. PLoS Biol. 2022 Mar 3;20(3):e3001561. .

Yin X, Willinger CM, Keefe J, Liu J, Fernández-Ortiz A, Ibáñez B, Peñalvo J, Adourian A, Chen G, Corella D, Pamplona R, Portero-Otin M, Jove M, Courchesne P, van Duijn CM, Fuster V, Ordovás JM, Demirkan A, Larson MG, Levy D. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 2020 Jan;51:102520. doi: 10.1016/j.ebiom.2019.10.046. Epub 2019 Dec 24.

Wolrab D, Jirásko R, Cífková E, Höring M, Mei D, Chocholoušková M, Peterka O, Idkowiak J, Hrnčiarová T, Kuchař L, Ahrends R, Brumarová R, Friedecký D, Vivo-Truyols G, Škrha P, Škrha J, Kučera R, Melichar B, Liebisch G, Burkhardt R, Wenk MR, Cazenave-Gassiot A, Karásek P, Novotný I, Greplová K, Hrstka R, Holčapek M. Lipidomic profiling of human serum enables detection of pancreatic cancer. Nat Commun. 2022 Jan 10;13(1):124.

German CA, Shapiro MD. Assessing Atherosclerotic Cardiovascular Disease Risk with Advanced Lipid Testing: State of the Science. Eur Cardiol. 2020 Jul 15;15:e56.

Mentias A, Aminian A, Youssef D, Pandey A, Menon V, Cho L, Nissen SE, Desai MY. Long-Term Cardiovascular Outcomes After Bariatric Surgery in the Medicare Population. J Am Coll Cardiol. 2022 Apr 19;79(15):1429-1437.

Brenton JN, Lehner-Gulotta D, Woolbright E, Banwell B, Bergqvist AGC, Chen S, Coleman R, Conaway M, Goldman MD. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):637-644. doi: 10.1136/jnnp-2022-329074. Epub 2022 Apr 13.

Antonio L, Wu FCW, Moors H, Matheï C, Huhtaniemi IT, Rastrelli G, Dejaeger M, O'Neill TW, Pye SR, Forti G, Maggi M, Casanueva FF, Slowikowska-Hilczer J, Punab M, Tournoy J, Vanderschu

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