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Episode 30. Management of High-Risk Myeloma
Manage episode 376847685 series 3369804
Innehåll tillhandahållet av Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Rajshekhar Chakraborty and Ashwin Kishtagari, Rajshekhar Chakraborty, Ashwin Kishtagari, and Edward Cliff eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.
In this episode, we discuss with Dr. Martin Kaiser how to identify and manage newly diagnosed high-risk multiple myeloma in the current era of effective frontline therapies. Here are the key studies that we touched upon:
1. Phase II OPTIMUM (MUKnine) trial in ultra-high-risk myeloma and PCL:
https://pubmed.ncbi.nlm.nih.gov/37315268/
2. Meta-analysis of >2500 patients with chromosome 1q21 abnormalities:
https://pubmed.ncbi.nlm.nih.gov/34092058/
3. Predicting ultra-high risk myeloma by molecular profiling (including SKY92 GEP signature):
https://pubmed.ncbi.nlm.nih.gov/32157174/
4. French data on adverse prognostic impact of del(1p32):
https://pubmed.ncbi.nlm.nih.gov/36375118/
5. S1211 study: The first high-risk enrichment RCT in myeloma (VRD vs Elo-VRD):
https://pubmed.ncbi.nlm.nih.gov/33357482/
6. Outcome of “double-hit” patients in MASTER and Dara-VRD arm of GRIFFIN trial:
https://ashpublications.org/blood/article/140/Supplement%201/10144/488521
7. Impact of Auto-Transplant on decreasing MRD burden in high-risk myeloma (including double-hits):
https://pubmed.ncbi.nlm.nih.gov/35731911/
8. Preliminary results from GMMG-CONCEPT trial in high-risk myeloma:
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