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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
Manage episode 424794497 series 3332773
In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes.
Article Citation:
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. SmithAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309
40 episoder
"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis
American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast
Manage episode 424794497 series 3332773
In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes.
Article Citation:
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. SmithAmerican Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309
40 episoder
Alla avsnitt
×1 "Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus 13:02
1 "Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium 7:50
1 "Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology 7:20
1 "Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses 5:56
1 "Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter 8:43
1 "Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis 8:25
1 "Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity 8:29
1 "Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis 4:39
1 "Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function 6:26
1 "Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis 7:07
1 "Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons 6:22
1 ”Got Guts” The Micro Version: Gastric Neuromuscular Transmission 5:29
1 ”Got Guts” The Micro Version: Gene expression and microbiome composition in EsoCaSR-/-mice 7:28
1 "Got Guts" Special Episode: The GI and Liver Section at the 2024 American Physiology Summit 11:26
1 ”Got Guts” The Micro Version: Pf Inhibits Inflammation-Induced Epithelial Break-Down 5:16
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