Collagen-Bound Interleukin 12 Converts “Cold” Tumors Into “Hot” Ones Oncology Times - OncTimes Talk podcast

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Innehåll tillhandahållet av Oncology Times. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Oncology Times eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

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Collagen-Bound Interleukin 12 Converts “Cold” Tumors Into “Hot” Ones

3M ago 14:51

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Innehåll tillhandahållet av Oncology Times. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Oncology Times eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

Although immunotherapies for patients with solid tumors such as melanoma can be dramatically successful, the majority of patients are resistant and require alternative treatments. While the cytokine interleukin-12 is well known for potentiating the effect of immunotherapies, such as checkpoint blockade, it couldn’t be used because of toxicity.

At the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Jun Ishihara, PhD, a lecturer at London’s Imperial College reported on a protein bioengineering approach in which IL/12 is bound to collagen from the extracellular matrix of the tumor. This targets the cytokine’s action to operate specifically on cancer while hopefully avoiding most of the off-target toxicities previously observed with unbound IL/12.

After the conference, OncTimesTalk’s Peter Goodwin called to see him at his London laboratory.

… continue reading

139 episoder

#Medicine #Oncology #Cancer #Oncology Times #Science #News #Health and Well-Being

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Collagen-Bound Interleukin 12 Converts “Cold” Tumors Into “Hot” Ones

Oncology Times - OncTimes Talk

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published 3M ago

Dela

Innehåll tillhandahållet av Oncology Times. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Oncology Times eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

Although immunotherapies for patients with solid tumors such as melanoma can be dramatically successful, the majority of patients are resistant and require alternative treatments. While the cytokine interleukin-12 is well known for potentiating the effect of immunotherapies, such as checkpoint blockade, it couldn’t be used because of toxicity.

At the 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Jun Ishihara, PhD, a lecturer at London’s Imperial College reported on a protein bioengineering approach in which IL/12 is bound to collagen from the extracellular matrix of the tumor. This targets the cytokine’s action to operate specifically on cancer while hopefully avoiding most of the off-target toxicities previously observed with unbound IL/12.

After the conference, OncTimesTalk’s Peter Goodwin called to see him at his London laboratory.

… continue reading

139 episoder

#Medicine #Oncology #Cancer #Oncology Times #Science #News #Health and Well-Being

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