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”Got Guts” the Micro Version with Gene Lamanilao

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Manage episode 374272019 series 3332773
Innehåll tillhandahållet av ajpgi. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av ajpgi eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration."

Treatment of advanced liver disease using surgical modalities is possible due to the liver’s innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria’s inherent role in liver regeneration.

Article Citation:

Key hepatoprotective roles of mitochondria in liver regeneration Gene G. Lamanilao, Murat Dogan, Prisha S. Patel, Shafquat Azim, Disha S. Patel, Syamal K. Bhattacharya, James D. Eason, Canan Kuscu, Cem Kuscu, and Amandeep Bajwa

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:3, G207-G218

  continue reading

32 episoder

Artwork
iconDela
 
Manage episode 374272019 series 3332773
Innehåll tillhandahållet av ajpgi. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av ajpgi eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.

In this micro podcast Dr. Gene G. Lamanilao The University of Tennessee Health Science Center, College of Medicine gives the listeners an overview the recently published manuscript titled "Key hepatoprotective roles of mitochondria in liver regeneration."

Treatment of advanced liver disease using surgical modalities is possible due to the liver’s innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria’s inherent role in liver regeneration.

Article Citation:

Key hepatoprotective roles of mitochondria in liver regeneration Gene G. Lamanilao, Murat Dogan, Prisha S. Patel, Shafquat Azim, Disha S. Patel, Syamal K. Bhattacharya, James D. Eason, Canan Kuscu, Cem Kuscu, and Amandeep Bajwa

American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:3, G207-G218

  continue reading

32 episoder

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