Bästa Smart Manufacturing podcaster (2025)

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132: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 2 14:57

2d ago14:57

14:57

Send us a text Artificial Intelligence (AI) is transforming industries worldwide, and biotechnology is no exception. In bioprocess development, AI is proving to be a game-changer, accelerating workflows, optimizing processes, and driving innovation. On the Smart Biotech Scientist Podcast, Reza Farahani, founder and CEO of Catalyze AI, shares his in…

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131: Combining AI and Biomanufacturing for Sustainable, Cost-Effective Therapeutics with Reza Farahani - Part 1 26:55

4d ago26:55

26:55

Send us a text The real-world applications of AI in biomanufacturing are transformative. From reducing drug development timelines to optimizing production yields, AI is making biomanufacturing more efficient and cost-effective. This, in turn, enhances global access to life-saving therapies. As AI continues to evolve, its potential to drive even gre…

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130: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason Foster - Part 2 20:15

9d ago20:15

20:15

Send us a text The intricacies of tech transfer and the challenges of scaling manufacturing processes are often underestimated in the biotechnology industry. Understanding these complexities is crucial for translating innovative scientific breakthroughs into commercially viable products. In the second part of the conversation with Jason Foster, CEO…

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129: Revolutionizing Cell Therapy Manufacturing: Reducing Costs to Reach More Patients with Jason Foster - Part 1 22:10

11d ago22:10

22:10

Send us a text One of the most urgent challenges in modern medicine is making cell and gene therapies widely accessible. These therapies, while groundbreaking in their safety and efficacy, often fall short when it comes to reaching patients. The reasons are manifold—high manufacturing costs, logistical complexities, and inefficiencies in the produc…

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128: The 7 Hidden Innovation Habits That Top Biotech Scientists Use Daily - Part 2 17:42

16d ago17:42

17:42

Send us a text The world of bioprocess development in biotechnology is evolving at an unprecedented pace, driven by the quest for breakthrough innovations. While new technologies play a significant role, what truly sets successful innovators apart are fundamental habits that foster an environment ripe for groundbreaking discoveries. In today's disc…

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127: The 7 Hidden Innovation Habits That Top Biotech Scientists Use Daily - Part 1 15:53

18d ago15:53

15:53

Send us a text In the fast-paced and highly regulated world of biotech development, maintaining an innovative spirit can sometimes feel like a Herculean task. Between optimizing cell culture processes and navigating strict regulatory requirements, it’s no wonder many scientists feel the weight of daily operations pressing down on their creativity. …

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126: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 2 20:31

23d ago20:31

20:31

Send us a text As biotechnology rapidly evolves, cell therapies are emerging as a groundbreaking frontier with the potential to transform medicine. In this episode of the Smart Biotech Scientist Podcast, host David Brühlmann speaks with Armon Sharei, founder and CEO of Portal Bio, about the complexities, challenges, and future of cell therapies. Ce…

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125: How to Enhance Cell Engineering Using Mechanical Intracellular Delivery with Armon Sharei - Part 1 21:35

25d ago21:35

21:35

Send us a text Intracellular delivery is essential for advancing research and clinical applications, yet it presents unique challenges when working with different cell types and biomolecules. In a recent episode of the Smart Biotech Scientist podcast, David Brühlmann spoke with Armon Sharei, the founder and CEO of Portal Bio, about the future of ce…

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124: Manufacturability: Why Most Protein Candidates Fail (And How to Pick Winners Early) with Susan Sharfstein - Part 2 17:32

1M ago17:32

17:32

Send us a text In part two of our insightful conversation, Dr. Susan Sharfstein builds on our previous discussion of developability assessment to explore how AI is revolutionizing protein manufacturability predictions. As a Professor of Nanoscale Science and Engineering at the University of Albany, she shares groundbreaking insights from her collab…

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123: Manufacturability: Why Most Protein Candidates Fail (And How to Pick Winners Early) with Susan Sharfstein - Part 1 22:35

1M ago22:35

22:35

Send us a text In this eye-opening episode, we dive deep into the critical yet often overlooked world of protein manufacturability with Dr. Susan Sharfstein, Professor of Nanoscale Science and Engineering at the University of Albany. As part of the broader developability assessment process, manufacturability evaluation helps determine whether a the…

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122: The Transformative World of Digital Solutions in Bioprocessing with Simon Wieninger - Part 2 17:58

1M ago17:58

17:58

Send us a text In the second part of this conversation on digital solutions in bioprocessing, David Brühlmann and Simon Wieninger, Business Manager Digital Solutions at Eppendorf Group, discuss real-world examples of labs revolutionizing their workflows through smart digitalization. From real-time data monitoring to intercontinental data sharing, S…

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121: The Transformative World of Digital Solutions in Bioprocessing with Simon Wieninger - Part 1 23:05

1M ago23:05

23:05

Send us a text Digital transformation is reshaping industries worldwide, and biotech is no exception. With the integration of cloud technologies, AI, and data harmonization, bioprocessing is becoming smarter, more efficient, and more innovative. Catching up with digital revolutions in other sectors, biotech now stands at the threshold of tremendous…

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120: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo - Part 2 21:23

1M ago21:23

21:23

Send us a text In the ever-evolving world of biotechnology, the integration of artificial intelligence (AI) and synthetic biology is driving unprecedented advancements. This transformative power was the focus of this podcast episode of the Smart Biotech Scientist, where host David Brühlmann engaged in a thought-provoking conversation with Haotian G…

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119: Innovating Protein Purification Using Synthetic Organelles and AI with Haotian Guo - Part 1 19:55

2M ago19:55

19:55

Send us a text Biotechnology is rapidly evolving as innovation addresses real-world needs. At the cutting edge of this evolution, synthetic biology and AI-driven protein design are revolutionizing our approach to complex processes like protein purification. In this episode of the Smart Biotech Scientist podcast, host David Brühlmann talks with Haot…

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118: Critical Bottlenecks and Breakthroughs in Cell Line Development with Andrea Gough - Part 2 15:16

2M ago15:16

15:16

Send us a text In the second part of our conversation with Andrea Gough, Senior Director for Advanced Instruments’ Solentim Portfolio, we’ll explore how AI and machine learning have, in recent years, begun to transform various aspects of biotechnology, including cell line development (CLD). Andrea shares insights into how these cutting-edge technol…

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117: Critical Bottlenecks and Breakthroughs in Cell Line Development with Andrea Gough - Part 1 23:33

2M ago23:33

23:33

Send us a text Cell line development (CLD) is a cornerstone of biologics production. This intricate process involves establishing a cell line capable of consistently producing a desired product, such as a therapeutic protein. While advancing science has refined numerous aspects of CLD, bottlenecks still exist, perpetuating challenges for scientists…

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116: Revolutionizing Biologics Development with Hyper Throughput Screening and AI with Jeremy Agresti - Part 2 16:43

2M ago16:43

16:43

Send us a text The intersection of artificial intelligence and biology presents immense opportunities for transforming bioprocess development. As the biotech industry continues to evolve, data-driven innovations are critical to optimizing biologics manufacturing. High-quality datasets stand at the forefront of this transformation, empowering resear…

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115: Revolutionizing Biologics Development with Hyper Throughput Screening and AI with Jeremy Agresti - Part 1 19:49

2M ago19:49

19:49

Send us a text Bioprocess development is transforming the biotech industry, driving innovations in life-changing therapies. Success hinges on simplifying complex mechanisms and adopting advanced technologies. By integrating high-throughput screening and artificial intelligence, we can streamline workflows, reduce trial-and-error, and speed up biolo…

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114: Weighing of Single-Use Bag Systems: Why Traditional Load Cells Are Holding You Back with Anders Tvegaard - Part 2 18:08

3M ago18:08

18:08

Send us a text Is your bioprocess facility wasting precious time and resources on traditional weighing system calibrations? In this eye-opening episode, Anders Tvegaard, COO of Eilersen Electric, reveals how digital load cell innovation is revolutionizing bioprocess monitoring and validation. Discover why weighing systems aren't the commodity techn…

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113: Weighing of Single-Use Bag Systems: Why Traditional Load Cells Are Holding You Back with Anders Tvegaard - Part 1 22:22

3M ago22:22

22:22

Send us a text What do furniture manufacturing and bioprocess weighing have in common? In this fascinating episode, Anders Tvegaard, COO of Eilersen Electric Digital Systems shares the remarkable story of how his company evolved from solving a furniture maker's wood humidity measurement problems to revolutionizing pharmaceutical manufacturing. Fift…

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112: AI Meets Biology: Why Domain Expertise Still Rules in the Age of Large Language Models with Lars Brandén - Part 2 23:41

3M ago23:41

23:41

Send us a text Can artificial intelligence revolutionize drug development and reduce the staggering 90% failure rate in clinical trials? In this insightful episode, Lars Brandén, Director of Biology at Kolibri, shares his vision for the future of personalized medicine. Drawing from his extensive experience bridging academia and industry, Lars explo…

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111: AI Meets Biology: Why Domain Expertise Still Rules in the Age of Large Language Models with Lars Brandén - Part 1 19:08

3M ago19:08

19:08

Send us a text In this episode, we explore the delicate dance between artificial intelligence and biological research with Lars Brandén, Director of Biology at Kolibri. From his early fascination with gene therapy to pioneering high-throughput screening centers at prestigious institutions, Lars shares invaluable insights on bridging the gap between…

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110: Spinning Like Earth: Designing Low-Shear Bioreactors for Better Cell Culture with Olivier Detournay - Part 2 16:24

3M ago16:24

16:24

Send us a text Could Earth's gentle movements hold the key to scaling up cell therapy production? In this fascinating episode, cellular biologist and entrepreneur Olivier Detournay (CSO of Cellura) reveals how his groundbreaking bioreactor design, inspired by geophysics, is transforming difficult cell culture processes. By mimicking natural planeta…

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109: Spinning Like Earth: Designing Low-Shear Bioreactors for Better Cell Culture with Olivier Detournay - Part 1 19:27

3M ago19:27

19:27

Send us a text What if the secret to growing sensitive cells lies in mimicking Earth's own movement? In this fascinating episode, cellular biologist Olivier Detournay, CSO of Cellura, reveals how studying planetary motion led to a groundbreaking bioreactor design that could transform cell therapy manufacturing. Drawing inspiration from geophysics r…

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108: From 1 Billion to 100: How AI is Cracking the Enzyme Discovery Code with David Schönauer - Part 2 26:35

3M ago26:35

26:35

Send us a text In this captivating episode, we dive deep into the groundbreaking intersection of artificial intelligence and enzyme engineering with David Schönauer, founder and CEO of Aminoverse. From university lab benches to pioneering AI-driven enzyme discovery, David shares how his startup is transforming the biotech landscape by making enzyme…

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107: From 1 Billion to 100: How AI is Cracking the Enzyme Discovery Code with David Schönauer - Part 1 19:11

3M ago19:11

19:11

Send us a text Ever wondered how scientists find the perfect enzyme among billions of possibilities? In this fascinating episode of the Smart Biotech Scientist podcast, host David Brühlmann sits down with David Schönauer, CEO of Aminoverse, who's revolutionizing enzyme engineering through artificial intelligence. As a biotech entrepreneur who trans…

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106: From Proteins to Cell Therapy: Why ATMPs Aren't Just Complex Biologics with Oliver Kraemer - Part 2 19:51

4M ago19:51

19:51

Send us a text In this insightful episode, Technical Development Leader at Flagship Pioneering Oliver Kraemer reveals why developing Advanced Therapy Medicinal Products (ATMPs) require a fundamental shift in thinking from traditional biologics development. Drawing from his extensive experience across Boehringer Ingelheim, Sanofi, and BMS, Kraemer c…

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105: From Proteins to Cell Therapy: Why ATMPs Aren't Just Complex Biologics with Oliver Kraemer - Part 1 21:52

4M ago21:52

21:52

Send us a text In this eye-opening episode, we explore the intricate landscape of Advanced Therapy Medicinal Products (ATMPs) with Oliver Kraemer, a technical development leader at Flagship Pioneering. Drawing from his extensive experience at industry giants like BMS, Sanofi, and Boehringer Ingelheim, Oliver challenges conventional wisdom about aut…

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104: One-Stop Shop vs. Specialist CDMO: A Scientist's Guide to CDMO Selection with Sigma Mostafa - Part 2 17:17

4M ago17:17

17:17

Send us a text Want to peek behind the curtain of a leading Contract Development and Manufacturing Organization (CDMO)? In this inspiring episode, KBI Biopharma's Chief Scientific Officer Sigma Mostafa reveals the intricate world of bioprocess development and manufacturing. Sigma shares game-changing insights into accelerating biologics development…

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103: One-Stop Shop vs. Specialist CDMO: A Scientist's Guide to CDMO Selection with Sigma Mostafa - Part 1 24:01

4M ago24:01

24:01

Send us a text In this insightful episode, we're joined by Sigma Mostafa, Chief Scientific Officer at KBI Biopharma, who shares crucial insights on selecting the right CDMO partner for biotech development. Sigma brings a unique blend of scientific rigor and practical experience to the discussion, having worked on both sides of the CDMO relationship…

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102: PAT Revolution: Decoding Your Bioprocess Like Never Before with Katharina Dahlmann - Part 2 15:17

4M ago15:17

15:17

Send us a text Struggling to unravel the complexities of your bioprocess? Prepare for a paradigm shift as we dive into the world of Process Analytical Technology (PAT) with Katharina Dahlmann who is Application and PAT Expert at Hamilton. This eye-opening episode dissects how PAT is redefining biologics manufacturing, balancing its immense potentia…

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101: PAT Revolution: Decoding Your Bioprocess Like Never Before with Katharina Dahlmann - Part 1 23:12

4M ago23:12

23:12

Send us a text Unlock the hidden potential of your bioprocess! In this eye-opening episode, David Brühlmann sits down with Katharina Dahlmann, Application and PAT Expert at Hamilton, to explore the game-changing world of Process Analytical Technology (PAT). Discover how PAT is revolutionizing biotech by providing unprecedented insights into cell be…

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100: From Raw Data to Actionable Insights: Unlocking the Power of Process Models with Fabian Feidl - Part 2 18:01

4M ago18:01

18:01

Send us a text Imagine predicting your bioprocess outcomes as easily as checking the weather forecast. Sound impossible? Not anymore. In this insightful episode, we dive deep into the world of digital twins and process models with Fabian Feidl, co-founder and CTO of DataHow. Discover how these cutting-edge tools are reshaping the biotech landscape,…

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99: From Raw Data to Actionable Insights: Unlocking the Power of Process Models with Fabian Feidl - Part 1 22:00

4M ago22:00

22:00

Send us a text Are you ready to decode the future of bioprocessing? In this eye-opening episode, we dive deep into the world of digital bioprocess development with Fabian Feidl, co-founder and CTO of DataHow. Discover how cutting-edge process models are transforming the biotech industry, bridging the gap between raw data and actionable insights. Ke…

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98: The Biomanufacturing Revolution: Bringing Game-changing Products to Market with James Ryall - Part 2 17:59

5M ago17:59

17:59

Send us a text Are you ready to dive into the cutting-edge world of biomanufacturing? In this episode, strategic consultant James Ryall unveils the staggering potential of bio-based products to revolutionize industries. From cultured meat to human breast milk, discover how cells are becoming the ultimate manufacturing facilities. James shares inval…

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97: The Biomanufacturing Revolution: Bringing Game-changing Products to Market with James Ryall - Part 1 24:24

5M ago24:24

24:24

Send us a text In this captivating episode, host David Brühlmann welcomes James Ryall, a strategic consultant with over two decades of experience in cell biology and regenerative medicine. From his groundbreaking work in skeletal muscle research to revolutionizing cultured meat production, James shares his fascinating journey through academia and i…

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96: AI in Bioprocess Development: The Game-Changer You Can't Ignore with Belma Alispahic - Part 2 19:53

5M ago19:53

19:53

Send us a text Are you ready to revolutionize your bioprocess development? Join David Brühlmann as he interviews Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode, who unveils the game-changing potential of AI in biopharma. Discover how AI is transforming the industry, from drug discovery to manufacturing, and learn why it's …

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95: AI in Bioprocess Development: The Game-Changer You Can't Ignore with Belma Alispahic - Part 1 20:37

5M ago20:37

20:37

Send us a text Is AI the secret weapon biotech scientists have been waiting for? In this eye-opening episode, we dive deep into the world of AI-driven bioprocess development with Belma Alispahic, Chief Scientific Officer and Co-Founder of AnalysisMode. Discover how AI is transforming the biotech landscape, from reducing downtime by 50% to unlocking…

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94: From Lab Coat to LinkedIn: Benjamin McLeod's Journey to Cell and Gene Therapy Influencer - Part 2 19:31

5M ago19:31

19:31

Send us a text In this electrifying episode, we dive deep into the future of biotech with biotech influencer Benjamin McLeod. From quantum AI mapping cellular interactions to the game-changing potential of process analytical technology, Ben, who is also a Cell & Gene Therapy Segment Lead at NanoMosaic, unveils how artificial intelligence is set to …

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93: From Lab Coat to LinkedIn: Benjamin McLeod's Journey to Cell and Gene Therapy Influencer - Part 1 24:04

5M ago24:04

24:04

Send us a text Discover how a failed optometry dream led Benjamin McLeod to become a leading voice in cell and gene therapy. In this eye-opening episode, Ben, who is a Cell & Gene Therapy Segment Lead at NanoMosaic, shares his unconventional path from lab work to LinkedIn stardom, revealing how he bridges the gap between R&D and marketing in biotec…

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92: Mass Transfer Secrets: Mastering Bubbles and kLa from Bench to Large-Scale Production with Lars Puiman & Rik Volger - Part 2 16:29

5M ago16:29

16:29

Send us a text Ever wondered why your perfectly optimized lab process falls apart at industrial scale? Mass transfer experts Lars Puiman and Rik Volger from the University of Delft reveal the hidden world of oxygen transfer and aeration that can make or break your production. Dive into the crucial differences between lab-scale and industrial-scale …

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91: Mass Transfer Secrets: Mastering Bubbles and kLa from Bench to Large-Scale Production with Lars Puiman & Rik Volger - Part 1 16:37

5M ago16:37

16:37

Send us a text Unlock the mysteries of oxygen transfer in bioreactors with mass transfer experts Lars Puiman and Rik Volger from the University of Delft. In this eye-opening episode, dive deep into the crucial world of kLa (oxygen mass transfer coefficient) and its impact on bioprocess scale-up. Discover why understanding kLa is essential for optim…

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90: Scale-Up Secrets: Cracking the Code of AAV Production with Ahmed Youssef - Part 2 25:14

5M ago25:14

25:14

Send us a text Dive into the cutting-edge world of gene therapy as we unravel the complexities of AAV production. In this insightful episode, Ahmed Youssef, a seasoned AAV expert and Senior Process Development Manager at Ascend, explains how you can navigate the complex world of AAV scale-up and learn why thinking outside the box is crucial for suc…

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89: Scale-Up Secrets: Cracking the Code of AAV Production with Ahmed Youssef - Part 1 20:08

6M ago20:08

20:08

Send us a text Unlock the mysteries of AAV manufacturing in this eye-opening episode! Ahmed, a seasoned AAV expert and Senior Process Development Manager at Ascend, reveals insider strategies for biotech scientists navigating the complex world of gene therapy production. Discover why quality is the cornerstone of successful AAV development and how …

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88: The Swiss Army Knife of Biotech: Unleashing the Power of Fractional Expertise 16:38

6M ago16:38

16:38

Send us a text Unlock the secret weapon of biotech success! In this eye-opening episode, host David Brühlmann reveals how fractional CTOs are revolutionizing drug development, inspired by Michael Jordan's approach to greatness. Learn how this innovative strategy can slash timelines, mitigate risks, and give your biotech company a competitive edge. …

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87: The Hidden Pitfalls of Bioprocess Development: Lessons from the Trenches 16:54

6M ago16:54

16:54

Send us a text Unlock the secrets of successful bioprocess development with host David Brühlmann as he shares hard-won lessons from his 15+ years of experience leading technology transfers and technology innovation projects. Discover why prioritizing process development is crucial for transforming groundbreaking science into life-changing therapies…

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86: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo Morbidelli - Part 2 23:01

6M ago23:01

23:01

Send us a text What if your biomanufacturing facility could run itself, optimize its own processes, and operate non-stop? This isn't science fiction – it's the cutting-edge reality Professor Massimo Morbidelli is helping to create. In this captivating episode, the bioprocessing pioneer unveils how AI, continuous manufacturing, and revolutionary mac…

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85: Bioprocess 4.0: Integrated Continuous Biomanufacturing with Massimo Morbidelli - Part 1 24:04

6M ago24:04

24:04

Send us a text Imagine a world where biologic drugs are produced faster, cheaper, and with unprecedented precision. In this episode, we dive into that future with Professor Massimo Morbidelli, a trailblazer in bioprocessing innovation. As a Professor Emeritus at ETH Zurich and Politecnico di Milano, and a co-founder of ChromaCon (now YMC) and DataH…

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84: The Hidden Potential of Shake Flasks: What Every Biotech Scientist Needs to Know with Jens Bayer - Part 2 23:17

6M ago23:17

23:17

Send us a text Are your shake flasks holding back your bioprocess development? Discover how to transform them into smart bioreactors! In this game-changing episode, we talk with Jens Bayer about the groundbreaking DOTS platform. He is a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientifi…

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83: The Hidden Potential of Shake Flasks: What Every Biotech Scientist Needs to Know with Jens Bayer - Part 1 18:25

6M ago18:25

18:25

Send us a text Are shake flasks outdated relics or untapped goldmines of bioprocess development? In this eye-opening episode, we dive deep with Jens Bayer, a deep tech entrepreneur and seasoned commercial leader, currently serving as Chief Commercial Officer at Scientific Bioprocessing. Jens shatters common misconceptions about shake flasks, reveal…

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