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Episode 18: DNA Recorders
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Innehåll tillhandahållet av Dr Jonny Coates. Allt poddinnehåll inklusive avsnitt, grafik och podcastbeskrivningar laddas upp och tillhandahålls direkt av Dr Jonny Coates eller deras podcastplattformspartner. Om du tror att någon använder ditt upphovsrättsskyddade verk utan din tillåtelse kan du följa processen som beskrivs här https://sv.player.fm/legal.
This week we discuss DNA recorders with Theresa Loveless (@TheresaLovele12), a Post Doc, at UC Irvine. DNA recorders can turn transient events into stable genomic ones and have been used to investigate cell fates and lineages. Join us as we find out more about how this is achieved and the incredible technology behind it!! We also chat about Theresa’s experience of preprinting and academia, and how it can be improved!!
Read the full preprint
https://www.biorxiv.org/content/10.1101/2021.11.05.467507v1.full
Whole-organism lineage tracing by combinatorial and cumulative genome editing: https://pubmed.ncbi.nlm.nih.gov/27229144/
molecular recordings by directed crispr spacer acquisition
https://pubmed.ncbi.nlm.nih.gov/27284167/
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts
https://pubmed.ncbi.nlm.nih.gov/33479121/
Prime Editor: https://www.nature.com/articles/s41434-021-00263-9
This episode was produced by Emma Wilson and edited by John D Howard .
If you enjoyed this show then hit that subscribe button and leave a review. If you love what we are trying to do then support us on Patreon https://www.patreon.com/preprintsinmotion where tiers start at as little as £1 a month!
For the latest podcast news and updates follow us on Twitter @MotionPod or visit our website; www.preprintsinmotion.com.
Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).
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