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Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
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Insightful conversations with leading experts in the field of health care, medical research, policy, and more from the New England Journal of Medicine (NEJM). Each episode examines the many complexities found at the junction of medicine and society.
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NEJM AI Grand Rounds

NEJM Group

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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations w ...
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Ida Sim is a professor of medicine at the University of California, San Francisco, and codirector of the Joint Program in Computational Precision Health at UC Berkeley and UCSF. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. I. Sim and C. Cassel. The Ethics of Relational AI — Expanding and Implementing the Belm…
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Featuring articles on tenecteplase for ischemic stroke within 4.5 to 24 hours after the stroke, risankizumab vs. ustekinumab for Crohn’s disease, nirmatrelvir–ritonavir as Covid-19 postexposure prophylaxis, and efanesoctocog alfa in children with hemophilia A; a review article on the management of insomnia; a case report of a woman with postpartum …
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In this episode of NEJM AI Grand Rounds, hosts Raj Manrai and Andy Beam interview Dr. Rohaid Ali and Dr. Fatima Mirza, a married couple and chief residents at Brown University. The conversation explores their innovative work applying AI to health care, focusing on two major projects: Using ChatGPT to simplify surgical consent forms, making them mor…
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Erin Fuse Brown is a professor of health services, policy, and practice at the Brown University School of Public Health and a member of the Journal’s Perspective Advisory Board. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. H. Rooke-Ley, S. Shah, and E.C. Fuse Brown. Medicare Advantage and Consolidation’s New …
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Featuring articles on semaglutide and chronic kidney disease in type 2 diabetes, felzartamab in kidney-transplant rejection, bulevirtide and peginterferon for chronic hepatitis D, and nirsevimab and hospitalization for RSV bronchiolitis; a review article on malnutrition in adults; a case report of an infant with vomiting and hypercalcemia; and Pers…
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Evan Mullen is a resident in the Department of Medicine at Stanford University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E. Mullen, E.J. Topol, and A. Verghese. Academic Freedom in America — In Support of Institutional Voices. N Engl J Med 2024;391:1-3.
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Featuring articles on stress ulcer prophylaxis during invasive mechanical ventilation, new therapies for hereditary angioedema, tissue factor–directed therapy in cervical cancer, and normalization of C1 inhibitor in a patient with hereditary angioedema; a review article on acute abdomen in the modern era; a Clinical Problem-Solving article on aggre…
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Nathaniel Chin is an associate professor in the Division of Geriatrics and Gerontology and medical director of the Alzheimer's Disease Research Center at the University of Wisconsin School of Medicine and Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. N.A. Chin and C.M. Erickson. Alzheimer’s Dise…
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Featuring articles on treatments for eosinophilic esophagitis, reteplase versus alteplase for acute ischemic stroke, dupilumab for COPD with type 2 inflammation, and brigatinib in NF2-related schwannomatosis; a review article on amyloidosis; a case report of a man with recurrent fever and liver lesions; and Perspectives on Alzheimer’s disease, biom…
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Christine Grady is chief of the Department of Bioethics at the National Institutes of Health Clinical Center. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S. Hendriks and C. Grady. Ethics and Highly Innovative Research on Brain Diseases. N Engl J Med 2024;390:2133-2136.…
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Featuring articles on combination therapy for diffuse large B-cell lymphoma, autosomal dominant Alzheimer’s disease, noninvasive ventilation for preoxygenation during emergency intubation, a novel anti-CD38 antibody in immune thrombocytopenia, and a glucose-responsive insulin for type 2 diabetes; a review article on congenital and acquired Chiari s…
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In this episode of the AI Grand Rounds podcast, Dr. Adam Rodman shares his unique journey from a historian to a physician deeply interested in the intersection of medicine and artificial intelligence. He highlights his unconventional path, driven by an obsession with epistemology and nosology, and his early exposure to AI through historical referen…
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Jessica Lewis is a research scientist at the Yale School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.B. Lewis and J.R. Ickovics. Expect With Me — Group Prenatal Care to Reduce Disparities. N Engl J Med 2024;390:2039-2040.
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Featuring articles on T-cell cancer after CAR T-cell therapy, the early diagnosis and treatment of COPD and asthma, and the implications of race adjustment in lung-function equations; a review article on diets; a case report of a woman with the worst headache of her life; and Perspectives on efforts toward equity and on feeling guilty.…
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Featuring articles on neoadjuvant immunotherapy for dMMR colon cancer, TAVR in patients with a small aortic annulus, gene editing and retinal degeneration, and the genetic diagnosis of rare diseases; a review article on disorders of magnesium; a case report of a woman with metastatic breast cancer; and a Perspective on malicious midwives, fruitful …
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Katharine Silbaugh is a professor at the Boston University School of Law. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Silbaugh, L. Del Valle, and C. Robertson. Toward a Tobacco-free Generation — A Birth Date–Based Phaseout Approach. N Engl J Med 2024;390:1837-1839.…
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Featuring articles on aficamten for obstructive hypertrophic cardiomyopathy; early blood-pressure reduction in acute stroke; interferon-γ in autoimmune polyendocrine syndrome type 1; video laryngoscopy for intubation in neonates; hunger, thirst, and Buridan’s ass; and global health law for a safer and fairer world; a review article on medical AI an…
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Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Demetre Daskalakis is the Director of the CDC’s National Center for Immunization and Respiratory Diseases. Hilary Marston is the Chief Medical Officer of the Food and Drug Administration. Stephen Morrissey, the interviewer, is the Executive Managing E…
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Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Jeanne Marrazzo is the director of the National Institute of Allergy and Infectious Diseases. Arnold Monto is emeritus professor of public health at the University of Michigan. Stephen Morrissey, the interviewer, is the Executive Managing Editor of th…
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Alicia Fernandez is a professor of medicine at the University of California, San Francisco. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A. Fernandez and M.H. Chin. Keep Your Eyes on the Prize — Focusing on Health Care Equity. N Engl J Med 2024;390:1733-1736.
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Featuring articles on andexanet and factor Xa inhibitor–associated hemorrhage, perioperative nivolumab in resectable lung cancer, olezarsen for familial chylomicronemia syndrome, and olezarsen for hypertriglyceridemia; a review article on climate change, extreme heat, and health; a case report of a woman with worsening rash; and Perspective article…
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In this episode of the NEJM AI Grand Rounds podcast, Dr. Nigam Shah, a distinguished Professor of Medicine at Stanford University and inaugural Chief Data Scientist for Stanford Health Care, shares his journey from training as a doctor in India to becoming a leading figure in biomedical informatics in the United States. He discusses the transformat…
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Joshua Sharfstein is distinguished professor of the practice in health policy and management at the Johns Hopkins Bloomberg School of Public Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.M. Sharfstein and L.O. Gostin. The Public Good on the Docket — The Supreme Court’s Evolving Approach to Public Hea…
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Featuring articles on gene editing in severe sickle cell disease and in transfusion-dependent β-thalassemia, thrombectomy for stroke with a large infarct, and recombinant ADAMTS13 in life-threatening immune thrombotic thrombocytopenic purpura; a review article on taste physiology; a case report of a woman with back pain, leg stiffness, and falls; a…
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Featuring articles on a monoclonal antibody to prevent malaria, apolipoprotein A1 and outcomes after myocardial infarction, transcatheter or surgical treatment of aortic-valve stenosis, and recombinant ADAMTS13 in congenital thrombotic thrombocytopenic purpura; a review article on cryptococcal disease in diverse hosts; a Clinical Problem-Solving on…
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Kevin Schulman is a professor of medicine at the Stanford University School of Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. K. Schulman and B. Richman. Hospital Consolidation and Physician Unionization. N Engl J Med 2024;390:1445-1447.
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Featuring articles on empagliflozin after acute myocardial infarction, CD7 CAR T cells with allogeneic stem-cell transplantation, FFR-guided complete revascularization for STEMI, and nutrition for moderate-to-late preterm infants; a review article on age-related hearing loss; a case report of a man with leg weakness; and Perspective articles on hos…
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